Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells.
Identifieur interne : 000392 ( Main/Exploration ); précédent : 000391; suivant : 000393Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells.
Auteurs : Zhilin Hu [République populaire de Chine] ; Guojun Qu [République populaire de Chine] ; Xiaoyan Yu [République populaire de Chine] ; Haojie Jiang [République populaire de Chine] ; Xiao-Lu Teng [République populaire de Chine] ; Lei Ding [République populaire de Chine] ; Qianwen Hu [République populaire de Chine] ; Xinwei Guo [République populaire de Chine] ; Yan Zhou [République populaire de Chine] ; Feng Wang [République populaire de Chine] ; Hua-Bing Li [République populaire de Chine] ; Lei Chen [République populaire de Chine] ; Jin Jiang [États-Unis] ; Bing Su [République populaire de Chine] ; Junling Liu [République populaire de Chine] ; Qiang Zou [République populaire de Chine]Source :
- Cell metabolism [ 1932-7420 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Femelle (MeSH), Lymphocytes T CD8+ (immunologie), Mâle (MeSH), Mélanome expérimental (anatomopathologie), Mélanome expérimental (immunologie), Mélanome expérimental (métabolisme), Phosphotransferases (Alcohol Group Acceptor) (immunologie), Phosphotransferases (Alcohol Group Acceptor) (métabolisme), Souris (MeSH), Souris transgéniques (MeSH).
- MESH :
- anatomopathologie : Mélanome expérimental.
- immunologie : Lymphocytes T CD8+, Mélanome expérimental, Phosphotransferases (Alcohol Group Acceptor).
- métabolisme : Mélanome expérimental, Phosphotransferases (Alcohol Group Acceptor).
- Animaux, Femelle, Mâle, Souris, Souris transgéniques.
English descriptors
- KwdEn :
- Animals (MeSH), CD8-Positive T-Lymphocytes (immunology), Female (MeSH), Male (MeSH), Melanoma, Experimental (immunology), Melanoma, Experimental (metabolism), Melanoma, Experimental (pathology), Mice (MeSH), Mice, Transgenic (MeSH), Phosphotransferases (Alcohol Group Acceptor) (immunology), Phosphotransferases (Alcohol Group Acceptor) (metabolism).
- MESH :
- chemical , immunology : Phosphotransferases (Alcohol Group Acceptor).
- immunology : CD8-Positive T-Lymphocytes, Melanoma, Experimental.
- metabolism : Melanoma, Experimental, Phosphotransferases (Alcohol Group Acceptor).
- pathology : Melanoma, Experimental.
- Animals, Female, Male, Mice, Mice, Transgenic.
Abstract
CD8+ T cell expansions and functions rely on glycolysis, but the mechanisms underlying CD8+ T cell glycolytic metabolism remain elusive. Here, we show that acylglycerol kinase (AGK) is required for the establishment and maintenance of CD8+ T cell metabolic and functional fitness. AGK deficiency dampens CD8+ T cell antitumor functions in vivo and perturbs CD8+ T cell proliferation in vitro. Activation of phosphatidylinositol-3-OH kinase (PI3K)-mammalian target of rapamycin (mTOR) signaling, which mediates elevated CD8+ T cell glycolysis, is tightly dependent on AGK kinase activity. Mechanistically, T cell antigen receptor (TCR)- and CD28-stimulated recruitment of PTEN to the plasma membrane facilitates AGK-PTEN interaction and AGK-triggered PTEN phosphorylation, thereby restricting PTEN phosphatase activity in CD8+ T cells. Collectively, these results demonstrate that AGK maintains CD8+ T cell metabolic and functional state by restraining PTEN activity and highlight a critical role for AGK in CD8+ T cell metabolic programming and effector function.
DOI: 10.1016/j.cmet.2019.05.016
PubMed: 31204281
Affiliations:
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280 South Chongqing Road, Shanghai 200025, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Ding, Lei" sort="Ding, Lei" uniqKey="Ding L" first="Lei" last="Ding">Lei Ding</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Qianwen" sort="Hu, Qianwen" uniqKey="Hu Q" first="Qianwen" last="Hu">Qianwen Hu</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell 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Road, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Yan" sort="Zhou, Yan" uniqKey="Zhou Y" first="Yan" last="Zhou">Yan Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Feng" sort="Wang, Feng" uniqKey="Wang F" first="Feng" last="Wang">Feng Wang</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Li, Hua Bing" sort="Li, Hua Bing" uniqKey="Li H" first="Hua-Bing" last="Li">Hua-Bing Li</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Lei" sort="Chen, Lei" uniqKey="Chen L" first="Lei" last="Chen">Lei Chen</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Jin" sort="Jiang, Jin" uniqKey="Jiang J" first="Jin" last="Jiang">Jin Jiang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Su, Bing" sort="Su, Bing" uniqKey="Su B" first="Bing" last="Su">Bing Su</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China. Electronic address: bingsu@sjtu.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Junling" sort="Liu, Junling" uniqKey="Liu J" first="Junling" last="Liu">Junling Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China. Electronic address: liujl@shsmu.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Biochemistry and Molecular Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Zou, Qiang" sort="Zou, Qiang" uniqKey="Zou Q" first="Qiang" last="Zou">Qiang Zou</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China. Electronic address: qzou1984@sjtu.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31204281</idno><idno type="pmid">31204281</idno><idno type="doi">10.1016/j.cmet.2019.05.016</idno><idno type="wicri:Area/Main/Corpus">000252</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000252</idno><idno type="wicri:Area/Main/Curation">000252</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000252</idno><idno type="wicri:Area/Main/Exploration">000252</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8<sup>+</sup> T Cells.</title><author><name sortKey="Hu, Zhilin" sort="Hu, Zhilin" uniqKey="Hu Z" first="Zhilin" last="Hu">Zhilin Hu</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Qu, Guojun" sort="Qu, Guojun" uniqKey="Qu G" first="Guojun" last="Qu">Guojun Qu</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Xiaoyan" sort="Yu, Xiaoyan" uniqKey="Yu X" first="Xiaoyan" last="Yu">Xiaoyan Yu</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Haojie" sort="Jiang, Haojie" uniqKey="Jiang H" first="Haojie" last="Jiang">Haojie Jiang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Biochemistry and Molecular Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Teng, Xiao Lu" sort="Teng, Xiao Lu" uniqKey="Teng X" first="Xiao-Lu" last="Teng">Xiao-Lu Teng</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Ding, Lei" sort="Ding, Lei" uniqKey="Ding L" first="Lei" last="Ding">Lei Ding</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Qianwen" sort="Hu, Qianwen" uniqKey="Hu Q" first="Qianwen" last="Hu">Qianwen Hu</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Guo, Xinwei" sort="Guo, Xinwei" uniqKey="Guo X" first="Xinwei" last="Guo">Xinwei Guo</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Yan" sort="Zhou, Yan" uniqKey="Zhou Y" first="Yan" last="Zhou">Yan Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Feng" sort="Wang, Feng" uniqKey="Wang F" first="Feng" last="Wang">Feng Wang</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Li, Hua Bing" sort="Li, Hua Bing" uniqKey="Li H" first="Hua-Bing" last="Li">Hua-Bing Li</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Lei" sort="Chen, Lei" uniqKey="Chen L" first="Lei" last="Chen">Lei Chen</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Jin" sort="Jiang, Jin" uniqKey="Jiang J" first="Jin" last="Jiang">Jin Jiang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Su, Bing" sort="Su, Bing" uniqKey="Su B" first="Bing" last="Su">Bing Su</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China. Electronic address: bingsu@sjtu.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Junling" sort="Liu, Junling" uniqKey="Liu J" first="Junling" last="Liu">Junling Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China. Electronic address: liujl@shsmu.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Biochemistry and Molecular Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Zou, Qiang" sort="Zou, Qiang" uniqKey="Zou Q" first="Qiang" last="Zou">Qiang Zou</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China. Electronic address: qzou1984@sjtu.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author></analytic><series><title level="j">Cell metabolism</title><idno type="eISSN">1932-7420</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>CD8-Positive T-Lymphocytes (immunology)</term><term>Female (MeSH)</term><term>Male (MeSH)</term><term>Melanoma, Experimental (immunology)</term><term>Melanoma, Experimental (metabolism)</term><term>Melanoma, Experimental (pathology)</term><term>Mice (MeSH)</term><term>Mice, Transgenic (MeSH)</term><term>Phosphotransferases (Alcohol Group Acceptor) (immunology)</term><term>Phosphotransferases (Alcohol Group Acceptor) (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Femelle (MeSH)</term><term>Lymphocytes T CD8+ (immunologie)</term><term>Mâle (MeSH)</term><term>Mélanome expérimental (anatomopathologie)</term><term>Mélanome expérimental (immunologie)</term><term>Mélanome expérimental (métabolisme)</term><term>Phosphotransferases (Alcohol Group Acceptor) (immunologie)</term><term>Phosphotransferases (Alcohol Group Acceptor) (métabolisme)</term><term>Souris (MeSH)</term><term>Souris transgéniques (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Phosphotransferases (Alcohol Group Acceptor)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Mélanome expérimental</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Lymphocytes T CD8+</term><term>Mélanome expérimental</term><term>Phosphotransferases (Alcohol Group Acceptor)</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term><term>Melanoma, Experimental</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Melanoma, Experimental</term><term>Phosphotransferases (Alcohol Group Acceptor)</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Mélanome expérimental</term><term>Phosphotransferases (Alcohol Group Acceptor)</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Melanoma, Experimental</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Male</term><term>Mice</term><term>Mice, Transgenic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Mâle</term><term>Souris</term><term>Souris transgéniques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">CD8<sup>+</sup> T cell expansions and functions rely on glycolysis, but the mechanisms underlying CD8<sup>+</sup> T cell glycolytic metabolism remain elusive. Here, we show that acylglycerol kinase (AGK) is required for the establishment and maintenance of CD8<sup>+</sup> T cell metabolic and functional fitness. AGK deficiency dampens CD8<sup>+</sup> T cell antitumor functions in vivo and perturbs CD8<sup>+</sup> T cell proliferation in vitro. Activation of phosphatidylinositol-3-OH kinase (PI3K)-mammalian target of rapamycin (mTOR) signaling, which mediates elevated CD8<sup>+</sup> T cell glycolysis, is tightly dependent on AGK kinase activity. Mechanistically, T cell antigen receptor (TCR)- and CD28-stimulated recruitment of PTEN to the plasma membrane facilitates AGK-PTEN interaction and AGK-triggered PTEN phosphorylation, thereby restricting PTEN phosphatase activity in CD8<sup>+</sup> T cells. Collectively, these results demonstrate that AGK maintains CD8<sup>+</sup> T cell metabolic and functional state by restraining PTEN activity and highlight a critical role for AGK in CD8<sup>+</sup> T cell metabolic programming and effector function.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31204281</PMID><DateCompleted><Year>2020</Year><Month>10</Month><Day>01</Day></DateCompleted><DateRevised><Year>2020</Year><Month>10</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1932-7420</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>2</Issue><PubDate><Year>2019</Year><Month>08</Month><Day>06</Day></PubDate></JournalIssue><Title>Cell metabolism</Title><ISOAbbreviation>Cell Metab</ISOAbbreviation></Journal><ArticleTitle>Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8<sup>+</sup> T Cells.</ArticleTitle><Pagination><MedlinePgn>290-302.e5</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1550-4131(19)30256-6</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cmet.2019.05.016</ELocationID><Abstract><AbstractText>CD8<sup>+</sup> T cell expansions and functions rely on glycolysis, but the mechanisms underlying CD8<sup>+</sup> T cell glycolytic metabolism remain elusive. Here, we show that acylglycerol kinase (AGK) is required for the establishment and maintenance of CD8<sup>+</sup> T cell metabolic and functional fitness. AGK deficiency dampens CD8<sup>+</sup> T cell antitumor functions in vivo and perturbs CD8<sup>+</sup> T cell proliferation in vitro. Activation of phosphatidylinositol-3-OH kinase (PI3K)-mammalian target of rapamycin (mTOR) signaling, which mediates elevated CD8<sup>+</sup> T cell glycolysis, is tightly dependent on AGK kinase activity. Mechanistically, T cell antigen receptor (TCR)- and CD28-stimulated recruitment of PTEN to the plasma membrane facilitates AGK-PTEN interaction and AGK-triggered PTEN phosphorylation, thereby restricting PTEN phosphatase activity in CD8<sup>+</sup> T cells. Collectively, these results demonstrate that AGK maintains CD8<sup>+</sup> T cell metabolic and functional state by restraining PTEN activity and highlight a critical role for AGK in CD8<sup>+</sup> T cell metabolic programming and effector function.</AbstractText><CopyrightInformation>Copyright © 2019 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Zhilin</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qu</LastName><ForeName>Guojun</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Xiaoyan</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Haojie</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Teng</LastName><ForeName>Xiao-Lu</ForeName><Initials>XL</Initials><AffiliationInfo><Affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ding</LastName><ForeName>Lei</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Qianwen</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Xinwei</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Yan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Feng</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Hua-Bing</ForeName><Initials>HB</Initials><AffiliationInfo><Affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Lei</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Jin</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Su</LastName><ForeName>Bing</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China. Electronic address: bingsu@sjtu.edu.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Junling</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China. Electronic address: liujl@shsmu.edu.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zou</LastName><ForeName>Qiang</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China. Electronic address: qzou1984@sjtu.edu.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>06</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cell Metab</MedlineTA><NlmUniqueID>101233170</NlmUniqueID><ISSNLinking>1550-4131</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>EC 2.7.1.-</RegistryNumber><NameOfSubstance UI="D017853">Phosphotransferases (Alcohol Group Acceptor)</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.94</RegistryNumber><NameOfSubstance UI="C025944">acylglycerol kinase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Cell Metab. 2019 Aug 6;30(2):233-234</RefSource><PMID Version="1">31390548</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018414" MajorTopicYN="N">CD8-Positive T-Lymphocytes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008546" MajorTopicYN="N">Melanoma, Experimental</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008822" MajorTopicYN="N">Mice, Transgenic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017853" MajorTopicYN="N">Phosphotransferases (Alcohol Group Acceptor)</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">AGK</Keyword><Keyword MajorTopicYN="Y">CD8+ T cells</Keyword><Keyword MajorTopicYN="Y">PI3K-mTOR</Keyword><Keyword MajorTopicYN="Y">PTEN</Keyword><Keyword MajorTopicYN="Y">glycolysis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>11</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>03</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>05</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>6</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>10</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>6</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31204281</ArticleId><ArticleId IdType="pii">S1550-4131(19)30256-6</ArticleId><ArticleId IdType="doi">10.1016/j.cmet.2019.05.016</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Hu, Zhilin" sort="Hu, Zhilin" uniqKey="Hu Z" first="Zhilin" last="Hu">Zhilin Hu</name></noRegion><name sortKey="Chen, Lei" sort="Chen, Lei" uniqKey="Chen L" first="Lei" last="Chen">Lei Chen</name><name sortKey="Ding, Lei" sort="Ding, Lei" uniqKey="Ding L" first="Lei" last="Ding">Lei Ding</name><name sortKey="Guo, Xinwei" sort="Guo, Xinwei" uniqKey="Guo X" first="Xinwei" last="Guo">Xinwei Guo</name><name sortKey="Hu, Qianwen" sort="Hu, Qianwen" uniqKey="Hu Q" first="Qianwen" last="Hu">Qianwen Hu</name><name sortKey="Jiang, Haojie" sort="Jiang, Haojie" uniqKey="Jiang H" first="Haojie" last="Jiang">Haojie Jiang</name><name sortKey="Li, Hua Bing" sort="Li, Hua Bing" uniqKey="Li H" first="Hua-Bing" last="Li">Hua-Bing Li</name><name sortKey="Liu, Junling" sort="Liu, Junling" uniqKey="Liu J" first="Junling" last="Liu">Junling Liu</name><name sortKey="Qu, Guojun" sort="Qu, Guojun" uniqKey="Qu G" first="Guojun" last="Qu">Guojun Qu</name><name sortKey="Su, Bing" sort="Su, Bing" uniqKey="Su B" first="Bing" last="Su">Bing Su</name><name sortKey="Teng, Xiao Lu" sort="Teng, Xiao Lu" uniqKey="Teng X" first="Xiao-Lu" last="Teng">Xiao-Lu Teng</name><name sortKey="Wang, Feng" sort="Wang, Feng" uniqKey="Wang F" first="Feng" last="Wang">Feng Wang</name><name sortKey="Yu, Xiaoyan" sort="Yu, Xiaoyan" uniqKey="Yu X" first="Xiaoyan" last="Yu">Xiaoyan Yu</name><name sortKey="Zhou, Yan" sort="Zhou, Yan" uniqKey="Zhou Y" first="Yan" last="Zhou">Yan Zhou</name><name sortKey="Zou, Qiang" sort="Zou, Qiang" uniqKey="Zou Q" first="Qiang" last="Zou">Qiang Zou</name></country><country name="États-Unis"><region name="Texas"><name sortKey="Jiang, Jin" sort="Jiang, Jin" uniqKey="Jiang J" first="Jin" last="Jiang">Jin Jiang</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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